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An Actual Insight into the Pathogenic Pathways of Ankylosing Spondylitis

Authors :
Emilia-Daniela Păsăran
Andreea Elena Diaconu
Corina Oancea
Andra-Rodica Bălănescu
Sorina Maria Aurelian
Corina Homentcovschi
Source :
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12800-12812 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Spondyloarthritis refers to a broad group of conditions that include ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and enteropathic arthritis associated with Crohn’s disease or ulcerative colitis. They have been classified by the ASAS group (ASsessment in Ankylosing Spondylitis) into axial spondyloarthritis and peripheral spondyloarthritis. Common features include the absence of autoantibodies, genetic predisposition, and clinical aspects such as axial joint involvement, peripheral manifestations, and extra-articular involvement. However, the pathogenic mechanisms remain complex and incompletely elucidated, despite the fact that the specialized literature has described several pathways that act in synergy: genetic predisposition, environmental factors (infections and mechanical stress), or innate and acquired immune mechanisms. Finally, an inflammatory response is triggered by the recruitment of a large number of inflammatory cells and the release of innate cytokines in the affected areas: joints or periarticular or extraarticular tissues. The current article aims to update and systematize the knowledge accumulated so far on this topic, focusing on the mechanisms that have been involved in the onset, progression, and severity of ankylosing spondylitis.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
46
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.811edce3b224e94a6ba1cd6ddb9cd6d
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb46110762