Back to Search
Start Over
Neuroprotective effect of ciclopirox olamine in retinal ischemia/reperfusion injury
- Source :
- BMC Molecular and Cell Biology, Vol 25, Iss 1, Pp 1-9 (2024)
- Publication Year :
- 2024
- Publisher :
- BMC, 2024.
-
Abstract
- Abstract Retinal ischemia–reperfusion (IR) injury is a basic pathological procedure in clinic and associated with various ischemic retinal diseases, including glaucoma, diabetic retinopathy, retinal vascular occlusion, etc. The purpose of this work is to investigate the effect of ciclopirox olamine (CPX) on retinal IR injury and further explore the underlying mechanism. In vitro assay exhibited that CPX exhibited significant neuroprotection against oxygen glucose deprivation (OGD) and oxidative stress-induced injuries in 661W photoreceptor cells. OGD injury showed a proinflammatory phenotype characterized by significantly increased production of cytokines (IL-6, IL-23 and TNF-α), while CPX significantly inhibited their secretion. In addition, the in vivo experiment demonstrated that CPX significantly preserved the normal thickness of the retina. Therefore, we suggest that CPX is identified in our research as a prospective therapeutic agent for retinal IR injury.
Details
- Language :
- English
- ISSN :
- 26618850
- Volume :
- 25
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- BMC Molecular and Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.810b3080fb88448cab720cdbc968ba49
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12860-024-00520-w