Effects of a skin neuropeptide (substance p) on cutaneous microflora.

Authors :: Lily Mijouin
Mélanie Hillion
Yasmina Ramdani
Thomas Jaouen
Cécile Duclairoir-Poc
Marie-Laure Follet-Gueye
Elian Lati
Florent Yvergnaux
Azzedine Driouich
Luc Lefeuvre
Christine Farmer
Laurent Misery
Marc G J Feuilloley
Source :: PLoS ONE, Vol 8, Iss 11, p e78773 (2013)
Publication Year :: 2013
Publisher :: Public Library of Science (PLoS), 2013.
Abstract: BACKGROUND: Skin is the largest human neuroendocrine organ and hosts the second most numerous microbial population but the interaction of skin neuropeptides with the microflora has never been investigated. We studied the effect of Substance P (SP), a peptide released by nerve endings in the skin on bacterial virulence. METHODOLOGY/PRINCIPAL FINDINGS: Bacillus cereus, a member of the skin transient microflora, was used as a model. Exposure to SP strongly stimulated the cytotoxicity of B. cereus (+553±3% with SP 10(-6) M) and this effect was rapid (

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