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Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Attempts to image activated macrophages in vivo have been hampered by selectivity and delivery problems. Here the authors develop a small molecule fluorescent probe specific to activated M1 and M2 macrophages, identify the orphan receptor Slc18b1/SLC18B1 as the mechanism of uptake, and use it to image atherosclerosis in mice.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.80a5a7ec76b4b3aaca86bee713b6628
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-08990-9