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Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis

Authors :
Dalia E. Gaddis
Lindsey E. Padgett
Runpei Wu
Chantel McSkimming
Veronica Romines
Angela M. Taylor
Coleen A. McNamara
Mitchell Kronenberg
Shane Crotty
Michael J. Thomas
Mary G. Sorci-Thomas
Catherine C. Hedrick
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here Gaddis et al. show that Apolipoprotein AI prevents the conversion of Treg cells into pro-atherogenic T follicular helper cells, and thus regulates the immune response during atherogenesis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8075bffece434699b9ec64bb663d89a5
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-03493-5