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The Controversies Surrounding Tocilizumab Administration Following Pathogen-Associated Molecular Pattern (PAMP) Induced by COVID-19
- Source :
- Journal of Pharmaceutical Care, Vol 8, Iss 3 (2020)
- Publication Year :
- 2020
- Publisher :
- Research Center for Rational Use of Drugs (RCRUD), 2020.
-
Abstract
- A new corona virus disease (COVID-19) is affected more than 5 million people worldwide to date and has become a global pandemic. Since there is no definitive cure for this life threatening disease, many clinical studies are underway in this regard. Pathogen-associated molecular patterns (PAMP) prompting by coronavirus seems to generate cellular, structural, and functional derangement induced by immune dysregulation and many biological abnormalities including cytokine storm. The role of IL-6 in viral pneumonia and also the impact of its inhibition on the prevention of organ damage are not known yet.IL-6 seems to behave as a double blade evil cytokine, with a valuable role in cell to cell natural physiological communication. Tocilizumab as an inhibitor of interleukin (IL)-6, may interrupt the paracrine system while causing dissemination of bacterial, fungal, and other viral infections, especially COVID-19, who are at high-risk development of sepsis and life-threatening superinfection.
Details
- Language :
- English
- ISSN :
- 23224630 and 23224509
- Volume :
- 8
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Pharmaceutical Care
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.805e4bb0e34e2d90fe6d908d2c11d1
- Document Type :
- article
- Full Text :
- https://doi.org/10.18502/jpc.v8i3.4549