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Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitus.

Authors :
Shinjiro Kodama
Tetsuya Yamada
Junta Imai
Shojiro Sawada
Kei Takahashi
Sohei Tsukita
Keizo Kaneko
Kenji Uno
Yasushi Ishigaki
Yoshitomo Oka
Hideki Katagiri
Source :
PLoS ONE, Vol 9, Iss 4, p e88602 (2014)
Publication Year :
2014
Publisher :
Public Library of Science (PLoS), 2014.

Abstract

Genetic factors play very important roles in the onset and progression of type 2 diabetes mellitus (T2DM). However, the genetic factors correlating with T2DM onset have not as yet been fully clarified. We previously found that copy number losses in the subtelomeric region on chromosome 4p16.3 were detected in early-onset Japanese T2DM patients (onset age

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
19326203
Volume :
9
Issue :
4
Database :
Directory of Open Access Journals
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
edsdoj.805aba361d304c4bb96a590a26444e14
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pone.0088602