The Predictive Value of Post Processing Total Motile Sperm Count of Semen on the Success of Intrauterine Insemination

Objectives: To study the predictive value of post-processing total motile sperm count (TMSC) on pregnancy rate in intrauterine insemination (IUI). Materials and Methods: Medical records were reviewed from August 2013 to January 2015. All unexplained infertile women or anovulation less than or equal to 35 years old, and initially treated with IUI were included. Small myoma, adenomyosis, adenomyoma, endometrial thickness less than 6 mm at 2-3 days before IUI and patients with previous pelvic surgery were excluded. The predictive values of post-processing TMSC parameters were analyzed regarding pregnancy outcomes with a receiver operating characteristic (ROC) curve. results: The overall pregnancy rate was 9.5% for all 218 couples with 314 IUI cycles. The cause of female infertility was unexplained for 75.16% of the sample population with anovulation at 24.84%. All parameters including duration of infertility, number of dominant follicles, largest dominant follicle diameter and endometrial thickness were unrelated to pregnancy outcomes. The ROC showed sensitivity, specificity, positive predictive value and negative predictive value of post-processing TMSC at 20x106/mm, with pregnancy outcomes of 50, 45, 48, and 47%, respectively. Conclusion: Post-processing TMSC was an unreliable predictive factor for IUI outcome.