Back to Search
Start Over
Bullous lichen planus-like reactions in a patient with renal cancer after receiving anti-programmed cell death-1 therapy
- Source :
- Dermatologica Sinica, Vol 38, Iss 1, Pp 55-58 (2020)
- Publication Year :
- 2020
- Publisher :
- Wolters Kluwer Medknow Publications, 2020.
-
Abstract
- Anti-programmed cell death 1 (anti-PD-1) agent is a promise in cancer immunotherapy for various advanced malignancies, but dermatologic toxicities are common during therapy. We report one advanced transitional cell carcinoma patient who developed multiple bullous skin lesions over bilateral lower extremities after anti-PD-1 antibody pembrolizumab treatment. Skin biopsy revealed subepidermal cleft, wedge-shaped hypergranulosis, saw-tooth acanthosis, and presence of interface band-like lymphohistiocytic infiltrate compatible with bullous lichen planus-like reactions. Potent topical steroid and temporary cessation of pembrolizumab relieved the skin eruptions. Early recognition and appropriate management of rare bullous dermatologic toxicities are critical in patients receiving immune checkpoint blockade therapy.
Details
- Language :
- English
- ISSN :
- 10278117 and 2223330X
- Volume :
- 38
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Dermatologica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.801f4f20837d4eee9cb0997eff825ba8
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/ds.ds_17_19