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Impact of different automated peritoneal dialysis modalities on the inflammatory profile of elderly patients with chronic kidney disease

Authors :
Marcia Maria Muniz de Queiroz Studart
Audrey Cecília Tonet Furioso
Joel Paulo Russomano Veiga
Mario Ernesto Rodrigues
Lucy de Oliveira Gomes
Clayton Franco Moraes
Source :
Brazilian Journal of Nephrology (2022)
Publication Year :
2022
Publisher :
Sociedade Brasileira de Nefrologia, 2022.

Abstract

Abstract Introduction: Chronic kidney disease, more prevalent in the elderly, is considered a public health issue worldwide. Objective: To evaluate the impact of automated, peritoneal dialysis modalities, intermittent and continuous, on the inflammatory profile of elderly people with chronic kidney disease. Methods: Prospective, cross-sectional and analytical study carried out in a dialysis clinic in Brasília - Brazil, with 74 elderly people aged 60 years or older. The patients underwent rapid Peritoneal Equilibration Test, clinical assessment, blood collection for biochemical and cytokine assessments, interleukin 6 and transforming growth factor beta 1, and answered a quality-of-life questionnaire (KDQOL-SF36). We used a 5% significance level for data analysis, associations and correlations. Results: Patients in the continuous modality had higher serum values of transforming growth factor beta 1 than those in the intermittent modality, which had higher peritoneal transforming growth factor beta 1, age and residual renal function than those in continuous mode. Interleukin 6 dosage in the peritoneum was associated with age, while serum IL-6 was associated with IL-6 in the peritoneum, time on dialysis and age. There was no association between the modality and the presence of diabetes, blood volume or nutritional status. Both modalities enable good adaptation to the dialysis treatment. Conclusion: Inflammation in automated peritoneal dialysis is mainly associated with low residual renal function, advanced age and longer time on therapy, and not to the type of dialysis performed.

Details

Language :
English, Portuguese
ISSN :
21758239
Database :
Directory of Open Access Journals
Journal :
Brazilian Journal of Nephrology
Publication Type :
Academic Journal
Accession number :
edsdoj.7f7726e731545b3885edd46847888b6
Document Type :
article
Full Text :
https://doi.org/10.1590/2175-8239-jbn-2022-0005en