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Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Oncoprotein SS18-SSX is a hallmark of synovial sarcoma. Here the authors report phase separation of SS18-SSX and the binding of SS18-SSX to chromatin remodeling complex are important for the transformation activity of the oncoprotein SS18-SSX.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7f20b03317d48be9aac837fe6866858
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-30447-9