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Heterocycle-guided synthesis of m-hetarylanilines via three-component benzannulation
- Source :
- Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 2208-2216 (2024)
- Publication Year :
- 2024
- Publisher :
- Beilstein-Institut, 2024.
-
Abstract
- A one-pot three-component synthesis of substituted meta-hetarylanilines from heterocycle-substituted 1,3-diketones has been developed. The electron-withdrawing power of the heterocyclic substituent (which can be estimated on the basis of calculated Hammett constants) in the 1,3-diketone plays a pivotal role in the studied reaction. The series of meta-hetarylanilines prepared (21–85% isolated yield) demonstrates the synthetic utility of the developed method.
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 20
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Beilstein Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7f00698508542289b0916db3451d957
- Document Type :
- article
- Full Text :
- https://doi.org/10.3762/bjoc.20.188