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Gastrin-producing G cells of gastric mucosa in Dexamethasone-treated rats
- Source :
- Kragujevac Journal of Science, Vol 2023, Iss 45, Pp 195-206 (2023)
- Publication Year :
- 2023
- Publisher :
- University of Kragujevac, Faculty of Science, 2023.
-
Abstract
- The systemic administration of glucocorticoids has not only strong beneficial anti-inflammatory and immunosuppressive effects but also numerous adverse health effects. Therefore, this study aimed to investigate the stereological and ultrastructural characteristics and distribution of gastrin-producing G cells in rat antral mucosa after 12 days of intraperitoneal administration of 2 mg/kg dexamethasone (DEX). In both groups of rats (DEX and control), the G cells were located at the base of the antral mucosal crypts, but in the DEX-treated rats, they were also found near the gastric lumen and showed an altered morphology compared to the basal cells. There were significant differences in the number of G cells per unit area and unit volume of antral mucosa between the groups studied. In the DEX-treated rats, the modified morphology and position of the antral G cells within the gastric units indicate their modified activity and possible impaired regulation of gastric acid production.
- Subjects :
- dexamethasone
gastrin
antrum
rats
Science
Subjects
Details
- Language :
- English
- ISSN :
- 14509636 and 24665509
- Volume :
- 2023
- Issue :
- 45
- Database :
- Directory of Open Access Journals
- Journal :
- Kragujevac Journal of Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7eea3e31d6284cbeb0f0aa97bb6afc11
- Document Type :
- article