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Oxymel: A systematic review of preclinical and clinical studies

Authors :
Narges Sharifi Darani
Mahdi Alizadeh Vaghasloo
Asma Kazemi
Hakima Amri
Thomas Rampp
Mohammad Hashem Hashempur
Source :
Heliyon, Vol 9, Iss 12, Pp e22649- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Background: Oxymel is a functional beverage with a rich historical background of use in multiple societies. Various simple and compound oxymels are prescribed in certain complementary and traditional medical systems, including traditional Persian Medicine. In recent years, numerous clinical and preclinical studies have been conducted in the pharmacy and food industry to investigate the efficacy of various oxymel formulations. This article aims to systematically review and summarize interventional studies on oxymel in both clinical research and animal models. Methods: Relevant articles were searched in Embase, MEDLINE, Web of Science Core Collection, Scopus, and Google Scholar from inception to July 2023 using the keyword “Oxymel” and its equivalents in other languages. Animal and human interventional studies were selected from the search results for review. Results: This review includes twenty studies, comprising twelve clinical trials, two case studies, and six animal studies. The most commonly reported actions of oxymel include positive effects on the cardiovascular system, as well as antioxidant and anti-inflammatory properties. Furthermore, compound oxymel formulations have demonstrated additional benefits depending on the inclusion of specific medicinal herbs. Conclusion: Based on our findings, oxymel appears to be a valuable functional food for healthy individuals and a potentially effective and safe treatment option for managing certain diseases such as asthma, obesity, and type 2 diabetes. However, further clinical trials with larger sample sizes and longer durations are needed to fully elucidate the potential side effects and benefits of both simple and compound oxymels in various disease states.

Details

Language :
English
ISSN :
24058440
Volume :
9
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.7eca399300014ee2a303abee0cd4d176
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2023.e22649