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Molecular mechanism of light-driven sodium pumping

Authors :
Kirill Kovalev
Roman Astashkin
Ivan Gushchin
Philipp Orekhov
Dmytro Volkov
Egor Zinovev
Egor Marin
Maksim Rulev
Alexey Alekseev
Antoine Royant
Philippe Carpentier
Svetlana Vaganova
Dmitrii Zabelskii
Christian Baeken
Ilya Sergeev
Taras Balandin
Gleb Bourenkov
Xavier Carpena
Roeland Boer
Nina Maliar
Valentin Borshchevskiy
Georg Büldt
Ernst Bamberg
Valentin Gordeliy
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

The Na+-pumping KR2 rhodopsin from Krokinobacter eikastus is a light-driven non-proton cation pump whose mechanism of pumping remains to be understood. Here authors solved crystal structures of the O-intermediate state of the pentameric form of KR2 and its D116N and H30A mutants, which sheds light on the mechanism of non-proton cation light-driven pumping.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7ebae3993e6420a849c16a42789609d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16032-y