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The combination of resveratrol and Bletilla striata polysaccharide decreases inflammatory markers of early osteoarthritis knee and the preliminary results on LPS‐induced OA rats

Authors :
Tzu‐Chieh Lin
Jhih‐Ni Lin
I‐Hsuan Yang
Christina Soong
Ya‐Jyun Liang
Subhaini Jakfar
Chun‐Che Yen
Hwa‐Chang Liu
Hsuan‐Yu Chen
Feng‐Huei Lin
Source :
Bioengineering & Translational Medicine, Vol 8, Iss 4, Pp n/a-n/a (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Abstract Osteoarthritis (OA) of the knee is characterized by progressive deterioration and loss of articular cartilage with associatedstructural and performance changes in the entire joint, and current treatments for OA only aim to relieve symptoms, rather than to prevent or reverse disease progression. Recently, treatments targeting “early osteoarthritis” (EOA) have attracted attention. However, during EOA stage, chondrocytes may change behaviors to express pro‐inflammatory cytokines and free radicals, which would cause detrimental effects to the synovial cavity and further cartilage wear. In this study, we combined resveratrol (Res) and Bletilla striata polysaccharide (BSP) as anti‐inflammatories and antioxidants to diffuse free radicals and to alleviate inflammation from the synovial cavity both short term and long term. The current study introduced a new method for harvesting BSP from as‐received Bletilla striata to achieve high yields, shortened extraction times, and maintained structure/functions. In addition, it combined Res and home‐extracted BSP (Res‐BSP) to alleviate oxidative stress and inflammation in a Lipopolysaccharide (LPS)‐induced OA model. The gene expressions of inflammatory genes iNOs, IL‐1β, IL‐6, and MMP‐13 were upregulated 5.7‐fold, 6.5‐fold, 8.6‐fold, and 4.5‐fold, respectively on OA‐like chondrocytes and the gene expressions were significantly downregulated to 3.3‐fold, 2.1‐fold, 4.9‐fold, and 0.1‐fold, respectively, once OA‐like chondrocytes were treated with Res‐BSP (p

Details

Language :
English
ISSN :
23806761
Volume :
8
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Bioengineering & Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.7dd44b72d15147aea64dc07407a2c4bb
Document Type :
article
Full Text :
https://doi.org/10.1002/btm2.10431