Back to Search Start Over

The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species.

Authors :
J Mark F Gardner
Nuha R Mansour
Andrew S Bell
Helena Helmby
Quentin Bickle
Source :
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
Publication Year :
2021
Publisher :
Public Library of Science (PLoS), 2021.

Abstract

Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the properties of a series of compounds we discovered through high throughput screening and have designed candidates for clinical development. The best compounds demonstrate clearance of both juvenile and adult S. mansoni worms in a mouse model of infection from a single oral dose of < 10 mg/kg. Several compounds in the series are predicted to treat schistosomiasis in humans across a range of species with a single oral dose of less than 5 mg/kg.

Details

Language :
English
ISSN :
19352727 and 19352735
Volume :
15
Issue :
7
Database :
Directory of Open Access Journals
Journal :
PLoS Neglected Tropical Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.7da0507681ce4b879d1f9d9c0948fc22
Document Type :
article
Full Text :
https://doi.org/10.1371/journal.pntd.0009490