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Structure of Some Green Tea Catechins and the Availability of Intracellular Copper Influence Their Ability to Cause Selective Oxidative DNA Damage in Malignant Cells

Authors :
Mohd Farhan
Asim Rizvi
Aamir Ahmad
Mohammad Aatif
Mir Waqas Alam
Sheikh Mumtaz Hadi
Source :
Biomedicines, Vol 10, Iss 3, p 664 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The possible roles of elevated endogenous copper levels in malignant cells are becoming increasingly understood at a greater depth. Our laboratory has previously demonstrated that tea catechins have the ability to mobilize endogenous copper and undergo a Fenton-like reaction that can selectively damage cancer cells. In this communication, by using a diverse panel of malignant cell lines, we demonstrate that the ability of the catechin family [(−)-epigallocatechin-3-gallate (EGCG), (−)-epigallocatechin (EGC), (−)-epicatechin (EC), and (+)-catechin (C)] to induce apoptosis is dependent on their structure. We further confirm that reactive oxygen species (ROS) are the terminal effectors causing copper-mediated DNA damage. Our studies demonstrate the role of cellular copper transporters CTR1 and ATP7A in the survival dynamics of malignant cells post-EGCG exposure. The results, when considered together with our previous studies, highlight the critical role that copper dynamics and mobilization plays in cancer cells and paves the way for a better understanding of catechins as nutraceutical supplements for malignancies.

Details

Language :
English
ISSN :
22279059
Volume :
10
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.7d7e4c7599d14793a2ee9810c653b749
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines10030664