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Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Current SpCas9 adenine base editors that minimise RNA off-target activities have constrained editing windows. Here the authors use domain insertion of TadA into Cas9 to narrow, expand or shift the editing window with RNA off-target minimization simultaneously
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7d58167fcfff4dcdb6820d39f8718c52
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-19730-9