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XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Authors :
Charlotte Blessing
Katja Apelt
Diana van den Heuvel
Claudia Gonzalez-Leal
Magdalena B. Rother
Melanie van der Woude
Román González-Prieto
Adi Yifrach
Avital Parnas
Rashmi G. Shah
Tia Tyrsett Kuo
Daphne E. C. Boer
Jin Cai
Angela Kragten
Hyun-Suk Kim
Orlando D. Schärer
Alfred C. O. Vertegaal
Girish M. Shah
Sheera Adar
Hannes Lans
Haico van Attikum
Andreas G. Ladurner
Martijn S. Luijsterburg
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7be3e1e274f3a94341103b43f7ce6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31820-4