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ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Authors :
Maik Pietzner
Robert Lorenz Chua
Eleanor Wheeler
Katharina Jechow
Julian D. S. Willett
Helena Radbruch
Saskia Trump
Bettina Heidecker
Hugo Zeberg
Frank L. Heppner
Roland Eils
Marcus A. Mall
J. Brent Richards
Leif-Erik Sander
Irina Lehmann
Sören Lukassen
Nicholas J. Wareham
Christian Conrad
Claudia Langenberg
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Genetic factors have been found to be associated with severe COVID-19. Here, the authors integrated genomic, proteomic, and single-cell data to identify ELF5 as a candidate risk gene with a possible role in respiratory epithelial cells, which are targeted by SARS-CoV-2.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7bddc4d6d42748edbe382377dc878d84
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-31999-6