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Effect of Dupilumab on Sleep Apnea Severity in Patients With Chronic Rhinosinusitis

Authors :
Sang-Wook Kim
Scott A. Sands
Daniel Vena
Lauren B. Hess
Nicole A. Calianese
Robert James Konefal
Luigi Taranto-Montemurro
Ali Azarbarzin
Charles A. Czeisler
Tanya M. Laidlaw
Andrew Wellman
Source :
Sleep Medicine Research, Vol 14, Iss 2, Pp 113-117 (2023)
Publication Year :
2023
Publisher :
Korean Society of Sleep Medicine, 2023.

Abstract

Patients with chronic rhinosinusitis (CRS) report improved sleep quality after dupilumab, an anti IL4/13 therapy. Concurrent CRS and obstructive sleep apnea (OSA) cases are not rare, and CRS seemingly raises nasal resistance. Thus, we hypothesized that improved sleep quality by dupilumab therapy in CRS patients might be due to lowered nasal resistance and subsequent improvement of unrecognized comorbid OSA. Patients with concurrent CRS and OSA were recruited. Nasal resistance was measured invasively with transnasal pressure and flow data collected during normal respiration in the supine position. Results from the first five participants did not support our hypothesis. Subjective and objective measures for CRS and nasal resistance values were improved with dupilumab therapy in CRS patients with nasal polyps. However, apnea severity and sleep-related subjective parameters did not change. In the patients with CRS without nasal polyps, no significant changes in either CRS or OSA-related measures were observed.

Details

Language :
English
ISSN :
20939175 and 22338853
Volume :
14
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Sleep Medicine Research
Publication Type :
Academic Journal
Accession number :
edsdoj.7bc5d55cce524b0eb41a374b8d9390c5
Document Type :
article
Full Text :
https://doi.org/10.17241/smr.2023.01641