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Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease

Authors :
Bethany N. Radford
Xiang Zhao
Tali Glazer
Malcolm Eaton
Danielle Blackwell
Shuhiba Mohammad
Lucas Daniel Lo Vercio
Jay Devine
Tali Shalom-Barak
Benedikt Hallgrimsson
James C. Cross
Henry M. Sucov
Yaacov Barak
Wendy Dean
Myriam Hemberger
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Placental dysfunction can affect heart development, but the prevalence of this causality has not been well established. Here, the authors use mouse genetic tools to show that the placenta may constitute a significant source of congenital heart defects.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 88446271
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7ba8844627134557901f769538bc270a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36740-5