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Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders (CROCTINO)

Authors :
Saif Huda
Ho Jin Kim
Anu Jacob
Joachim Havla
Adriana Roca-Fernández
Philipp Albrecht
Jacqueline Palace
Maria Isabel Leite
Friedemann Paul
Alexander U Brandt
Srilakshmi M Sharma
Su-Kyung Jung
Jae-Won Hyun
Frederike Cosima Oertel
Claudia Chien
Romain Marignier
Nasrin Asgari
Elena H Martinez-Lapiscina
Orhan Aktas
Letizia Leocani
Svenja Specovius
Hanna G Zimmermann
Charlotte Bereuter
Lawrence J Cook
Marco Aurélio Lana Peixoto
Mariana Andrade Fontenelle
Alejandro Rubio Diaz
Fereshte Ashtari
Rahele Kafieh
Alireza Dehghani
Mohsen Pourazizi
Lekha Pandit
Anitha Dcunha
Marius Ringelstein
Eugene May
Caryl Tongco
Marco Pisa
Marta Radaelli
Hadas Stiebel-Kalish
Mark Hellmann
Itay Lotan
Sasitorn Siritho
Jérôme de Seze
Thomas Senger
Caroline Tilikete
Alvaro Cobo Calvo
Denis Bernardi Bichuetti
Ivan Maynart Tavares
Kerstin Soelberg
Ayse Altintas
Rengin Yildirim
Uygur Tanriverdi
Zoe Rimler
Allyson Reid
Yang Mao-Draayer
Ibis Soto de Castillo
Michael R Yeaman
Terry J Smith
Source :
BMJ Open, Vol 10, Iss 10 (2020)
Publication Year :
2020
Publisher :
BMJ Publishing Group, 2020.

Abstract

Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD.Participants The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices.Findings to date The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline.Future plans We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
20446055
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
BMJ Open
Publication Type :
Academic Journal
Accession number :
edsdoj.7ba318a4ff4549fca6b9c7e70cf727b5
Document Type :
article
Full Text :
https://doi.org/10.1136/bmjopen-2019-035397