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Regulation of erythroid differentiation in K562 cells by the EPAS1-IRS2 axis under hypoxic conditions
- Source :
- Frontiers in Cell and Developmental Biology, Vol 11 (2023)
- Publication Year :
- 2023
- Publisher :
- Frontiers Media S.A., 2023.
-
Abstract
- Red blood cells (RBCs) produced in vitro have the potential to alleviate the worldwide demand for blood transfusion. Hematopoietic cell differentiation and proliferation are triggered by numerous cellular physiological processes, including low oxygen concentration (
- Subjects :
- erythropoiesis
EPAS1
IRS2
hypoxia
K562 cells
Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 2296634X
- Volume :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Cell and Developmental Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7b87cca23764c3cb06bdd866817840a
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/fcell.2023.1161541