Banana Peel-Derived Dendrite-Shaped Au Nanomaterials with Dual Inhibition Toward Tumor Growth and Migration

Yu Liu,1,* Xiangwei Song,2,* Fei Cao,3 Fengshun Li,3 Manyu Wang,3 Yalan Yang,3 Mingzhuo Liu,4 Anwen Liu,1 Hongbo Xin,3 Xiaolei Wang2,3 1Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2College of Chemistry, Nanchang University, Nanchang 330038, People’s Republic of China; 3Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330038, People’s Republic of China; 4Department of Burns, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaolei WangInstitute of Translational Medicine, Nanchang University, Hong Gu Tan New District, 1299 Xuefu Road, Nanchang 330088, People’s Republic of ChinaTel +86 18679850415Email wangxiaolei@ncu.edu.cnPurpose: In order to prepare functional Au nanoparticles with low toxicity and high antitumor properties, we have used fruit waste (banana peel) to synthesize a new dendrite-shaped gold nanoparticle and used it for the treatment of tumors.Methods: Dendrite-shaped gold nanoparticle (Au-dendrite) was synthesized through a facile hydrothermal process. The banana peel was used as both the reducing agent and the protective agent for reducing chloroauric acid to obtain Au-dendrite. The safety assessment of the Au-dendrite was conducted by H&E staining of the mouse’s eyelid skin and CCK-8 assay. The antitumor effects were evaluated through in vitro tumor cytotoxicity experiments and in vivo treatment of animal tumors.Results: In this work, a new type of gold nanomaterial (Au-dendrite) was synthesized by using a common agricultural waste (banana peel) through a facile hydrothermal process without any extra chemical reducing agent or protective agent. Subsequent experiments showed that, compared with some classical Au nanomaterials, the as-synthesized gold nanocomposites have superior biocompatibility and impressive characteristics of dual inhibition toward tumor growth and migration.Conclusion: We successfully synthesized a dendrite-shaped gold nanocomposite which was derived from a common agricultural waste (banana peel). A facile and environmentally friendly synthetic process was proposed accordingly without regular chemical additives. The as-prepared Au-dendrite nanocomposites not only had better biocompatibility than some classical gold nanoparticles but also exhibited unique advantages in tumor inhibition.Keywords: nanomaterials, Au nanoparticles, biocompatibility