High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Authors :: Yiqun Zhang
Fengju Chen
Nuno A. Fonseca
Yao He
Masashi Fujita
Hidewaki Nakagawa
Zemin Zhang
Alvis Brazma
PCAWG Transcriptome Working Group
PCAWG Structural Variation Working Group
Chad J. Creighton
PCAWG Consortium
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

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