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WNT-Pathway Activation in IBD-Associated Colorectal Carcinogenesis: Potential Biomarkers for Colonic Surveillance

Authors :
Marian M. H. Claessen
Marguerite E. I. Schipper
Bas Oldenburg
Peter D. Siersema
G. Johan A. Offerhaus
Frank P. Vleggaar
Source :
Cellular Oncology, Vol 32, Iss 4, Pp 303-310 (2010)
Publication Year :
2010
Publisher :
Hindawi Limited, 2010.

Abstract

Objectives: The Wnt-pathway dominates the sporadic carcinogenesis whereas p53 plays a pivotal role in the colitis-associated counterpart. The expression of Wnt-signaling proteins and p53 during colitis-associated carcinogenesis was determined.

Details

Language :
English
ISSN :
15705870 and 18758606
Volume :
32
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Cellular Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.7b22a73ba65746b0940c0b649fbcdcaf
Document Type :
article
Full Text :
https://doi.org/10.3233/CLO-2009-0503