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Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

Authors :
Tingting Li
Xiaojian Han
Chenjian Gu
Hangtian Guo
Huajun Zhang
Yingming Wang
Chao Hu
Kai Wang
Fengjiang Liu
Feiyang Luo
Yanan Zhang
Jie Hu
Wang Wang
Shenglong Li
Yanan Hao
Meiying Shen
Jingjing Huang
Yingyi Long
Shuyi Song
Ruixin Wu
Song Mu
Qian Chen
Fengxia Gao
Jianwei Wang
Shunhua Long
Luo Li
Yang Wu
Yan Gao
Wei Xu
Xia Cai
Di Qu
Zherui Zhang
Hongqing Zhang
Na Li
Qingzhu Gao
Guiji Zhang
Changlong He
Wei Wang
Xiaoyun Ji
Ni Tang
Zhenghong Yuan
Youhua Xie
Haitao Yang
Bo Zhang
Ailong Huang
Aishun Jin
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7abf996e0f9d4da6b7b08529e0aeb206
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26539-7