Recent Development and Applications of Polydopamine in Tissue Repair and Regeneration Biomaterials

Kai Guo,1,* Yong Wang,1,* Zi-Xuan Feng,1 Xiao-Ying Lin,1 Zhang-Rui Wu,1 Xin-Cao Zhong,1 Ze-Ming Zhuang,1 Tao Zhang,1 Jian Chen,2 Wei-Qiang Tan1 1Department of Plastic Surgery, Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Department of Ultrasonography, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Chen, Department of Ultrasonography, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang Province, People’s Republic of China, Email chenjianzuj4h@zju.edu.cn Wei-Qiang Tan, Department of Plastic Surgery, Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China, Email tanweixxxx@zju.edu.cnAbstract: The various tissue damages are a severe problem to human health. The limited human tissue regenerate ability requires suitable biomaterials to help damage tissue repair and regeneration. Therefore, many researchers devoted themselves to exploring biomaterials suitable for tissue repair and regeneration. Polydopamine (PDA) as a natural and multifunctional material which is inspired by mussel has been widely applied in different biomaterials. The excellent properties of PDA, such as strong adhesion, photothermal and high drug-loaded capacity, seem to be born for tissue repair and regeneration. Furthermore, PDA combined with different materials can exert unexpected effects. Thus, to inspire researchers, this review summarizes the recent and representative development of PDA biomaterials in tissue repair and regeneration. This article focuses on why apply PDA in these biomaterials and what PDA can do in different tissue injuries. Keywords: polydopamine, biomaterial, tissue damage, tissue regeneration