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Magneto-responsive Cell Culture Substrates that can be Modulated in situ

Authors :
Federica Crippa
Barbara Rothen-Rutishauser
Alke Petri-Fink
Source :
CHIMIA, Vol 73, Iss 1-2 (2019)
Publication Year :
2019
Publisher :
Swiss Chemical Society, 2019.

Abstract

Abstract: Understanding the interaction between cells and their environment is fundamental for mechanobiology. To mimic the behavior of cells in physiological and pathological conditions, synthetic substrates must have topographical and/or mechanical properties that evolve in time. Dynamic substrates mainly rely on stimuli-responsive materials where an external stimulus induces controlled variations in topography or mechanics. Herein, we describe the development of a dynamic cell culture substrate where mechanical properties are reversibly tuned in situ using magnetically-responsive superparamagnetic iron oxide nanoparticles (SPIONs).

Details

Language :
German, English, French
ISSN :
00094293 and 26732424
Volume :
73
Issue :
1-2
Database :
Directory of Open Access Journals
Journal :
CHIMIA
Publication Type :
Academic Journal
Accession number :
edsdoj.7a69cbd3054742169199c0f6641882c0
Document Type :
article
Full Text :
https://doi.org/10.2533/chimia.2019.51