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Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR

Authors :
Ming-Lun Yeh
Po-Cheng Liang
Pei-Chien Tsai
Shu-Chi Wang
Jennifer Leong
Eiichi Ogawa
Dae Won Jun
Cheng-Hao Tseng
Charles Landis
Yasuhito Tanaka
Chung-Feng Huang
Jun Hayashi
Yao-Chun Hsu
Jee-Fu Huang
Chia-Yen Dai
Wan-Long Chuang
Mindie H. Nguyen
Ming-Lung Yu
Source :
Cancers, Vol 13, Iss 14, p 3455 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, p < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (p < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival.

Details

Language :
English
ISSN :
20726694
Volume :
13
Issue :
14
Database :
Directory of Open Access Journals
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
edsdoj.7a681b0af4d1ba0cd0f9ffa99e31a
Document Type :
article
Full Text :
https://doi.org/10.3390/cancers13143455