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Unveiling the Role of HGF/c-Met Signaling in Non-Small Cell Lung Cancer Tumor Microenvironment

Authors :
Shuxi Yao
Xinyue Liu
Yanqi Feng
Yiming Li
Xiangtian Xiao
Yuelin Han
Shu Xia
Source :
International Journal of Molecular Sciences, Vol 25, Iss 16, p 9101 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Non-small cell lung cancer (NSCLC) is characterized by several molecular alterations that contribute to its development and progression. These alterations include the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), human epidermal growth factor receptor 2 (HER2), and mesenchymal–epithelial transition factor (c-MET). Among these, the hepatocyte growth factor (HGF)/c-MET signaling pathway plays a crucial role in NSCLC. In spite of this, the involvement of the HGF/c-MET signaling axis in remodeling the tumor microenvironment (TME) remains relatively unexplored. This review explores the biological functions of the HGF/c-MET signaling pathway in both normal and cancerous cells, examining its multifaceted roles in the NSCLC tumor microenvironment, including tumor cell proliferation, migration and invasion, angiogenesis, and immune evasion. Furthermore, we summarize the current progress and clinical applications of MET-targeted therapies in NSCLC and discuss future research directions, such as the development of novel MET inhibitors and the potential of combination immunotherapy.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
25
Issue :
16
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.7a2ad47ffe7b4d0cbb50ee09fa85124f
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms25169101