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HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.79e6f94830242d2a35e5f6ab7dac919
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-00182-7