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Copper-Catalyzed N-Arylation of Pyranoquinolinones with Boronic Acids at Room Temperature without Ligand
- Source :
- Catalysts, Vol 13, Iss 7, p 1060 (2023)
- Publication Year :
- 2023
- Publisher :
- MDPI AG, 2023.
-
Abstract
- Pyranoquinolinones synthesized from citral were used for Cu-catalyzed N-arylation with a wide range of arylboric acids. The reaction proceeded well with a broad substrate scope, providing a direct way to access highly functional pyranoquinolinone core structure derivatives in yields of up to 80%. Compared to citral, the compounds we obtained have a much better inhibitory effect on HeLa cervical cancer cells, and compound 3p has an IC50 value of 4.6 μM, lower than cisplatin’s 5.9 μM.
- Subjects :
- citral
pyranoquinolinone
N-arylation
Chemical technology
TP1-1185
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 20734344
- Volume :
- 13
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Catalysts
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.79c728232a234126833803bb9a714ffa
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/catal13071060