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LINC01354 enhances the proliferation and invasion of lung cancer cells by regulating miR-340-5p/ATF1 signaling pathway

Authors :
Gaojie Yang
Chongyi Yang
Yahui She
Zuojun Shen
Peng Gao
Source :
Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 3737-3744 (2019)
Publication Year :
2019
Publisher :
Taylor & Francis Group, 2019.

Abstract

Recent studies showed that long non-coding RNAs (lncRNAs) could play critical roles in tumors progression. However, the performance of LINC01354 is still limited in non-small cell lung cancer (NSCLC). In the current study, our results showed that LINC01354 was significantly increased in NSCLC tissues and cell lines. High LINC01354 expression was associated with advanced TNM stage and poor prognosis in NSCLC patients. Loss-of-function assays revealed that knockdown of LINC01354 reduced lung cancer cells proliferation and invasive ability in vitro. Subsequently, mechanism studies showed that LINC01354 positively regulated the ATF1 expression via competitive binding to miR-340-5p. Therefore, our results illustrated that LINC01354 might act as an oncogenic role by modulating the miR-340-5p/ATF1 axis, providing a novel therapeutic therapy for NSCLC treatment.

Details

Language :
English
ISSN :
21691401 and 2169141X
Volume :
47
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Artificial Cells, Nanomedicine, and Biotechnology
Publication Type :
Academic Journal
Accession number :
edsdoj.797c04dea2724ae1a20b440834da4921
Document Type :
article
Full Text :
https://doi.org/10.1080/21691401.2019.1667816