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Familial Sarcoidosis in Taiwan

Authors :
Reury-Perng Perng
Kun-Ta Chou
Hsi Chu
Yu-Mei Chung
Source :
Journal of the Formosan Medical Association, Vol 106, Iss 6, Pp 499-503 (2007)
Publication Year :
2007
Publisher :
Elsevier, 2007.

Abstract

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology and is uncommon in Taiwan. No cases of familial sarcoidosis have been reported in Taiwan. In this article, we report a mother and son pair who had sarcoidosis. The 56-year-old mother sought medical help for chronic cough for 3 months in 1993. Enlarged mediastinal lymph nodes were demonstrated on chest computed tomography. Besides, two small erythematous papules on her face were observed. Mediastinoscopic biopsy and skin biopsy showed non-caseating granulomatous inflammation. Sarcoidosis was thus diagnosed. The human leukocyte antigen (HLA)-typing of the patient was HLA-A2, A11, B35, B39, CW4, CW7, DR8 and DQ6. Eleven years later, her son was also diagnosed with sarcoidosis proved by mediastinoscopic biopsy. His HLA-typing was HLA-A2, A24, B39, B48, CW7, CW8, DR8 and DQ6. This is the first report of familial sarcoidosis in Chinese people. More cases are needed for further investigation of genetic predisposition among Chinese people.

Details

Language :
English
ISSN :
09296646
Volume :
106
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Journal of the Formosan Medical Association
Publication Type :
Academic Journal
Accession number :
edsdoj.797439c9250245fc893e7e8f8f4a8f10
Document Type :
article
Full Text :
https://doi.org/10.1016/S0929-6646(09)60301-6