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Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- Anti-VEGF therapy often produces limited beneficial effects in cancer patients. Here, the authors show that discontinuation of anti-VEGF cancer therapy in xenografts-bearing mice increases cancer cells extravasation and intravasation in liver through the host-derived VEGF.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.79582752f03043d7b3b6d8145bb72174
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms12680