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Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination
- Source :
- Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
- Publication Year :
- 2023
- Publisher :
- BMC, 2023.
-
Abstract
- Highlights AhR regulates remyelination following cuprizone-induced demyelination. Deletion of AhR in adult microglia restrains efficient remyelination. Microglial AhR deficiency causes myelin debris accumulation and impairs phagocytic function. Microglial AhR mediates phagocytosis of microglia via SYK.
Details
- Language :
- English
- ISSN :
- 17422094
- Volume :
- 20
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Neuroinflammation
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.78ded7c098b9420fa6ec5ddad818fc9a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12974-023-02764-3