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Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Antibiotic resistance through multidrug efflux is a major hurdle in antibiotic development. Here, authors experimentally demonstrate that EmrE, a small multidrug resistance efflux pump from E. coli, can confer resistance or susceptibility depending on the small molecule substrate.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.78d3e70700c04c05bf5b159674cdf840
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-35410-2