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2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists
- Source :
- CHIMIA, Vol 58, Iss 9 (2004)
- Publication Year :
- 2004
- Publisher :
- Swiss Chemical Society, 2004.
-
Abstract
- A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. ?1 and M1 receptors) and are active in vivo .
Details
- Language :
- German, English, French
- ISSN :
- 00094293 and 26732424
- Volume :
- 58
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- CHIMIA
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.78b5258c9904237b4bbb3f669504de2
- Document Type :
- article
- Full Text :
- https://doi.org/10.2533/000942904777677579