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RNA localization is a key determinant of neurite-enriched proteome

Authors :
Alessandra Zappulo
David van den Bruck
Camilla Ciolli Mattioli
Vedran Franke
Koshi Imami
Erik McShane
Mireia Moreno-Estelles
Lorenzo Calviello
Andrei Filipchyk
Esteban Peguero-Sanchez
Thomas Müller
Andrew Woehler
Carmen Birchmeier
Enrique Merino
Nikolaus Rajewsky
Uwe Ohler
Esteban O. Mazzoni
Matthias Selbach
Altuna Akalin
Marina Chekulaeva
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Subcellular localization of RNAs and proteins is important for polarized cells such as neurons. Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their cell bodies and neurites, providing a unique resource for future studies on neuronal polarity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.78855abe544f4175b8a66cdc42637e8a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-00690-6