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DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia
- Source :
- Haematologica, Vol 104, Iss 8 (2019)
- Publication Year :
- 2019
- Publisher :
- Ferrata Storti Foundation, 2019.
-
Abstract
- The prognostic implications of DNMT3A genotype in T-cell acute lymphoblastic leukemia are incompletely understood. We performed comprehensive genetic and clinico-biological analyses of T-cell acute lymphoblastic leukemia patients with DNMT3A mutations treated during the GRAALL-2003 and -2005 studies. Eighteen of 198 cases (9.1%) had DNMT3A alterations. Two patients also had DNMT3A mutations in non-leukemic cell DNA, providing the first potential evidence of age-related clonal hematopoiesis in T-cell acute lymphoblastic leukemia. DNMT3A mutation was associated with older age (median 43.9 years vs. 29.4 years, P
- Subjects :
- Diseases of the blood and blood-forming organs
RC633-647.5
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Volume :
- 104
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7874af4303e437f94ab5be0fb3f19e0
- Document Type :
- article
- Full Text :
- https://doi.org/10.3324/haematol.2018.197848