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A novel scale based on biomarkers associated with COVID-19 severity can predict the need for hospitalization and intensive care, as well as enhanced probabilities for mortality

Authors :
Eduardo Nieto-Ortega
Alejandro Maldonado-del-Arenal
Lupita Escudero-Roque
Diana Ali Macedo-Falcon
Ana Elena Escorcia-Saucedo
Adalberto León-del-Ángel
Alejandro Durán-Méndez
María José Rueda-Medécigo
Karla García-Callejas
Sergio Hernández-Islas
Gabriel Romero-López
Ángel Raúl Hernández-Romero
Daniela Pérez-Ortega
Estephany Rodríguez-Segura
Daniela Montaño‑Olmos
Jeffrey Hernández-Muñoz
Samuel Rodríguez-Peña
Montserrat Magos
Yanira Lizeth Aco-Cuamani
Nazareth García-Chávez
Ana Lizeth García-Otero
Analiz Mejía-Rangel
Valeria Gutiérrez-Losada
Miguel Cova-Bonilla
Alma Delia Aguilar-Arroyo
Araceli Sandoval-García
Eneyda Martínez-Francisco
Blanca Azucena Vázquez-García
Aldo Christiaan Jardínez-Vera
Alejandro Lechuga-Martín del Campo
Alberto N. Peón
Source :
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Abstract Prognostic scales may help to optimize the use of hospital resources, which may be of prime interest in the context of a fast spreading pandemics. Nonetheless, such tools are underdeveloped in the context of COVID-19. In the present article we asked whether accurate prognostic scales could be developed to optimize the use of hospital resources. We retrospectively studied 467 files of hospitalized patients after COVID-19. The odds ratios for 16 different biomarkers were calculated, those that were significantly associated were screened by a Pearson’s correlation, and such index was used to establish the mathematical function for each marker. The scales to predict the need for hospitalization, intensive-care requirement and mortality had enhanced sensitivities (0.91 CI 0.87–0.94; 0.96 CI 0.94–0.98; 0.96 CI 0.94–0.98; all with p

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.7868584f58504c87ab007f088d5a7504
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-023-30913-4