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Highly Pathogenic Clone of Shiga Toxin–Producing Escherichia coli O157:H7, England and Wales
- Source :
- Emerging Infectious Diseases, Vol 24, Iss 12, Pp 2303-2308 (2018)
- Publication Year :
- 2018
- Publisher :
- Centers for Disease Control and Prevention, 2018.
-
Abstract
- We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin–producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. Infection with the stx2a clone was a significant risk factor for bloody diarrhea (OR 4.61, 95% CI 2.24–9.48; p
Details
- Language :
- English
- ISSN :
- 10806040 and 10806059
- Volume :
- 24
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.78550fdc07748f091b923084dc82b63
- Document Type :
- article
- Full Text :
- https://doi.org/10.3201/eid2412.180409