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Bipartite network models to design combination therapies in acute myeloid leukaemia

Authors :
Mohieddin Jafari
Mehdi Mirzaie
Jie Bao
Farnaz Barneh
Shuyu Zheng
Johanna Eriksson
Caroline A. Heckman
Jing Tang
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Identifying effective drug combinations to treat cancer is a challenging task, either experimentally or computationally. Here, the authors develop a bipartite network modelling approach to propose drug combination strategies in acute myeloid leukaemia using patient and cell line drug screening data.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7835c36e17114c85aee2f92d7a628683
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29793-5