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The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and progenitor cells.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.77ff00f53b1049f3aa2acb231a637d78
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-01834-4