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SARS-CoV-2 binding and neutralizing antibody levels after Ad26.COV2.S vaccination predict durable protection in rhesus macaques

Authors :
Ramon Roozendaal
Laura Solforosi
Daniel J. Stieh
Jan Serroyen
Roel Straetemans
Anna Dari
Muriel Boulton
Frank Wegmann
Sietske K. Rosendahl Huber
Joan E. M. van der Lubbe
Jenny Hendriks
Mathieu Le Gars
Liesbeth Dekking
Dominika N. Czapska-Casey
Nuria Guimera
Sarah Janssen
Sarah Tete
Abishek Chandrashekar
Noe B. Mercado
Jingyou Yu
Wouter Koudstaal
Juan J. Perez-Ruixo
Jerry Sadoff
Dan H. Barouch
Hanneke Schuitemaker
Roland Zahn
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Several COVID-19 vaccines have received emergency approval, but durability of protection is unclear. Here, the authors describe correlates of protection (CoP) for the Ad26.COV2.S vaccine in rhesus macaques and report that CoP predict the protection observed 6 months post vaccination.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.77c130d228d404b88e0e8b1e5e20f78
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26117-x