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Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis

Authors :
Matteo Lucchini
Lorenzo Maggi
Elena Pegoraro
Massimiliano Filosto
Carmelo Rodolico
Giovanni Antonini
Matteo Garibaldi
Maria Lucia Valentino
Gabriele Siciliano
Giorgio Tasca
Valeria De Arcangelis
Chiara De Fino
Massimiliano Mirabella
Source :
Cells, Vol 10, Iss 5, p 1146 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in the sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed the sensitivity/specificity of anti-cN1A antibodies in an Italian cohort of s-IBM patients, searching for a potential correlation with clinical data. We collected clinical data and sera from 62 consecutive s-IBM patients and 62 other inflammatory myopathies patients. Testing for anti-cN1A antibodies was performed using a commercial ELISA. Anti-cN1A antibodies were detected in 23 s-IBM patients, resulting in a sensitivity of 37.1% with a specificity of 96.8%. Positive and negative predictive values were 92.0% and 60.6%, respectively. We did not find significant difference regarding demographic variables, nor quadriceps or finger flexor weakness. Nevertheless, we found that anti-cN1A-positive patients presented significantly lower scores in IBMFRS item 1 (swallowing, p = 0.045) and more frequently reported more severe swallowing problems, expressed as an IBMFRS item 1 score ≤ 2 (p < 0.001). We confirmed the low sensitivity and high specificity of anti-cN1A Ab in s-IBM patients with a high positive predictive value. The presence of anti-CN1A antibodies identified patients with a greater risk of more severe dysphagia.

Details

Language :
English
ISSN :
20734409
Volume :
10
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.77be9b7962384bb9bd7e52a07a956e80
Document Type :
article
Full Text :
https://doi.org/10.3390/cells10051146