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Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that kinesin-13 functions by stabilizing a curved tubulin conformation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.77b0f1dd0244051951a29439456c549
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-00091-9